Coca leaves -a treatment for cocaine dependence.

Hi folks,
cocaleaves2I just wanted to share with you a very interesting book a colleague sent to me the other day. Its all about using coca leaves to help treat cocaine dependence. It goes into great detail about this ‘tried and tested’  treatment, looking at cocaine and its alkaloids, its’ uses over the years,  and everything you ever wanted to know about coca leaves. useful stuff about freebasing and crack, the reward system and how cocaine works in the brain, and lots of interesting stuff about coca and why and how one can use it as a treatment for cocaine dependence. All in chunks that are easy to read and aren’t overwhelming or dense. (link to the book below).

The book is entitled Brief Review of Oral Cocaine for the Treatment of Cocaine Dependence.’ Written by Luis M. Llosa MD. Obviously, it talks in detail about coca (leaves) and its uses as a treatment. It claims to have been used for hundreds of years in the Andes and that “References of oral cocaine use (as alkaloid) have shown that traditional doses do not produce intoxication, behavioral disorders or lead to

.”cocaineleaves“After the digestive absorption of oral cocaine, the concentrations in blood rise slowly in about 10 to 15 minutes. The slower and more sloped peak in blood levels is thought to be responsible for the apparent low rate of addiction of the oral route. The physiological and psychological effects of oral cocaine last twice as long as those when used by aspiration, three times as those used by IV route and five to ten times longer than those when smoked. This gives it many therapeutic advantages: a slow absorption avoiding its accumulation and toxicity, low blood concentrations, low but sensible physiological and psychological effects ”

It was fascinating to read about all the drugs NIDA (National Insitute for Drug Abuse) in the US, have tried and tested to look for answers in how to treat cocaine dependence. I thought you guys would appreciate seeing some of them:

Amantadine, Baclofen, Bupropion, Naltrexone, Propranolol, Tiagabine,
Yohimbine, Dextrometorphan, Dronabinol, GBR12909 (Vanoxerine),
LAAM, LY544344, Methamphetamine, Modafinil, Aripripazole,
Buprenorphine, Clonidine, Naltrexone Depot, Selegiline, Topiramate,
Desipramine,Disulfiram, Fluoxetine, GCP44352, L-DOPA/Carbi,
N-Acetyl-aspartate, Atomoxetine, Bup/naloxone, Cocaine Vaccine,
Progesterone, Sertraline, Venlafaxine, d-Amphetamine, Divalproex,
Gabapentin, Hydromorphone, Lofexidine, Memantine, Methadone (Ivan
Montoya-NIDA/CPDD Meeting 2006).

Other substances under investigation in the last years are Nacetylcysteine, Cabergolide, Ondansetron, Diltiazen, Reserpine,
Selegiline, Vigabatrin, Oral Cocaine (Llosa 2007; Gorelick 2009)


Phew! That was a mouthful!

The author,  Llosa, in 1994, published the results of the first study performed with oral cocaine (as coca tea) to control cocaine addiction. In 1994 Llosa presented the results of the first double-blind trial as agonist therapy performed with oral cocaine as coca tablets Then, in 2005 Llosa & Llosa presented in the CPDD 67th annual meeting the review of oral cocaine as agonist therapy in cocaine dependence. The author concludes that “Orally cocaine contained in coca leaves has been consumed by Andean people for thousand years for work, social and spiritual purposes without users show signs of diseases and behavioral disorders.”

Llosa also contests that “The use of oral cocaine as agonist therapy meets the criteria for
substitution (replacement) therapies.  The review of the use of cocaine by oral route as agonist therapy has demonstrated efficiency to control cocaine dependence.”

Fortunately, Llosa does tell us how we might use these substances if we had access to coca leaves in sufficient quantities but also describes how they are used (and bought legally) in Peru, for the very same thing. All in all its a great book, a brief review at 28 pages (I think there may be a larger book on sale somewhere?) but I was certain BP readers would be interested in this little gem and it’s all here to download for free!

Thanks to Andres for locating this marvel.


Click this link below for the book Brief Review of Oral Cocaine for the Treatment of Cocaine Dependence








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