Updated with added text and information in 2011, from  a BP article in ISSUE 2blk_poppy_dtlsml.jpg

As you may know from our first issue, our Science on Substances feature is going to try to keep you informed about the variety of drugs that are currently involved in research trials around the world. Drugs used for detox, maintenance and abstinence, drugs that get you stoned and drugs used for your health and wellbeing, we’ll try and explain them all. This issue we introduce naltrexone…

SThere has been quite a lot of interest in naltrexone, not just in the UK but around the world. However, it is not just a single treatment option. There are various ways of using naltrexone – as part of a ‘rapid’ detox and as a daily dose to maintain abstinence. So, this issue we thought we should introduce naltrexone – its origins, its uses and its future.

What is Naltrexone and How Does it Work?

For heroin, (and other opiates such as methadone, morphine, palfium, codeine etc), to produce their effects – and get you stoned – they need to be able to attach themselves to small areas in the brain and nervous system called receptor sites. Naltrexone not only blocks these receptor sites, which prevents any opiates from working, but also displaces or removes any existing opiates that currently occupy those sites. Such drugs are called ‘opiate antagonists’ – they antagonise (to put it mildly!) any opiate. This means that if you take naltrexone when you have an opiate ‘habit’, you will find yourself withdrawing quickly and intensely as the opiates are rapidly (rather than slowly) removed from your receptor sites, and your body reacts to their absence. However, if you’ve already detoxed, taking naltrexone may help keep you abstinent as using heroin simply will not work. Naltrexone is sometimes referred to as a ‘non-drug’ because it doesn’t really have any effect other than blocking the effects of opiates. Naltrexone is long lasting – from 24 to 72 hours depending on the dose, and it comes as a tablet, or as an implant.

It is closely related to Naloxone (or Narcan), the ‘pure’ opiate antagonist which doctors use for opiate overdoses; but naloxone only works when injected and lasts for only a short time – less than an hour.

The Origins of Naltrexone

Naltrexone is a relatively new drug in the UK, becoming available in 1985 and receiving its product license in 1988. However, it has been used in the US since the early 70’s when Nassau County Jail (Long Island) initiated the Narcotic Antagonist Jail Work Release Program. Non-violent prisoners with a history of opiate misuse were allowed out during the day to attend work/training courses as long as they were administered naltrexone regularly (in tablet form). Unfortunately, as addicts were relegated to the bottom of the jails ‘trust ladder’ this was the only way these prisoners (the majority in Nassau County Jail) would ever have been admitted to this type of programme. The use of Naltrexone was pioneered in this country by Dr. Colin Brewer at the Stapleford Centre. Drawing on American experiences, he used it along with ‘strong sedation’ to provide users with greatly accelerated detoxes that were over in 48 – 72 hours and felt less unpleasant than traditional 14 – 21 days reducing methadone regimes. Doctors at the University of Vienna in Austria then developed the Ultra Rapid Detox technique using naltrexone with a short general anesthesia so that patients were unconscious for most of the detox. Details of this technique were first published in 1988. Dr Brewer further developed the technique resulting in a compromise between the Ultra Rapid and Rapid detox by using naltrexone and ‘strong sedation’ to provide users with greatly accelerated withdrawals without the added expense and intensive nursing that was required using anesthesia. The idea behind naltrexone is that if an opiate user can stay ‘clean’ for some time, then it is easier for people to learn to change their drug-using behaviour patterns. If heroin no longer ‘works’ then the user will stop scoring and stop hanging around drug using and places friends. But naltrexone has its detractors. Freudian types and others, who believe that people use drugs because of personal and emotional problems, say that naltrexone will do nothing to confront or deal with such issues. However, it is now thought by many that the problems many drug users have are a result of their addiction and not the cause. Therefore, if a person can be kept straight for a while, many of their ‘problems’ may disappear. However, it is worth remembering that naltrexone only works for opiates and not other drugs such as amphetamines, barbiturates or cocaine.

Naltrexone and its Uses (note: prices from 2000-2001

The main use of naltrexone is for the treatment of alcohol dependence. After publication of the first two randomized, controlled trials in 1992, a number of studies have confirmed its efficacy in reducing frequency and severity of relapse to drinking.The multi-center COMBINE study had recently proven the usefulness of naltrexone in an ordinary, primary care setting, without adjunct psychotherapy.

Naltrexone and Alcohol

The main use of naltrexone was actually for the treatment of alcohol dependence. After publication of the first two randomized, controlled trials in 1992, a number of studies have confirmed its efficacy in reducing frequency and severity of relapse to drinking. The standard regimen is one 50 mg tablet per day. Initial problems of nausea usually disappear after a few days, and other side effects (e.g., heightened liver enzymes) are rare. Drug interactions are not significant,unless you are an opiate user as well of course. Naltrexone has two effects on alcohol consumption. The first is to reduce craving while naltrexone is being taken. The second, referred to as the Sinclair Method, occurs when naltrexone is taken in conjunction with normal drinking, and this reduces craving over time. The first effect persists only while the naltrexone is being taken, but the second persists as long as the alcoholic does not drink without first taking naltrexone.

Naltrexone tablets – 50 mg tablets taken daily. Of course, it only works as long as you take it – which is why clinics stress the importance of having someone to supervise the taking of the tablets. Naltrexone tablets are available on the NHS and can be prescribed by any doctor.

Advantages – Easily available and relatively cheap.

Disadvantages – Only work if you take them.

Naltrexone Implant – inserted after any detox to maintain abstinence. A one inch incision is made under local anaesthetic in the lower abdomen or the back of upper arm. They are about 1.4cm in diameter and approx 9mm thick. Effects last from 6 – 12 weeks, and then patients need the implant renewed.

Advantages – You can’t forget to take it, which makes relapse on opiates practically impossible, (good for those who don’t have someone to support them).

Disadvantages – minor surgery and a small scar, occasional infection/inflammation at site, four times more expensive than tablets and not currently available on the NHS. Naltrexone implants have not been produced by a major drug company and should still be regarded as experimental. COST only available privately – approx £ 370 for outpatient insertion).

Rapid Opiate Detox Under General Anaesthesia – (NOTE: as of 2011, this has actually become procedure by many doctors and academics – and opiate users. If you are considering this treatment, BP would urge detailed research into the subject and to seek advice from others in drugs the field.) Premedication is prescribed 12 hours belofore the procedure starts. After further premedication with anti-withdrawal drugs and sedatives, naloxone is used by injection to detach the opiates from the receptors in the brain – speeding up the withdrawal process. Instead of taking 2-5 days for withdrawals to peak, the worst of the symptoms are over in a few hours. During this acute phase, patients are fully anaesthetised in an intensive care unit for 4-6 hours, then kept sleeping for up to 14 hours. Rapid detoxification under general anaesthesia involves an unconscious patient and requires intubation and external ventilation. Many patients can return home the following day (with supervision) whilst some may need a second day of nursing. Doesn’t completely eliminate withdrawals but once you are awake, you start to feel better rather than worse. Out-patient follow-up is usually included.

Advantages – Believed to be more comfortable than other methods, quickest return to work, naltrexone implants can also be inserted whilst anaesthetized.

Disadvantages – always inherent risk with general anaesthetic, some users awake still feeling sick, but these symptoms do get better. Procedure is expensive, potentially risky (has been fatal) for those people with bad health problems.

COST: £ 3700, a bit more if you are receiving the implant as well.

Rapid Opiate Detox Under Sedation (Also called 5 Day Detox) With this method you are in hospital for about 5 days. If you’re on methadone, you may be required to transfer to morphine or other opiates a week beforehand. After admission you are given generous amounts (depends on your interpretation of generous!) of sedatives and anti withdrawal drugs. After 3-4 days naltrexone is started and rapid withdrawals commence. Aftercare included.

Advantages – no anaesthetic only sedation so lower risk to patient, most people have little recall of event, it’s a lot cheaper than general anaesthetic.

Disadvantages -over sedation is avoided so it may not always control withdrawals – this causes some patients to leave without completion. At least a week is needed off work and there is some discomfort. Mixed reviews by users.

COST: about £2250

A version of this technique can also be done at home, with clinics providing a nurse, or (cheapest of all) a friend to act as carer and supervise the person whilst they are sedated. This way it is much less expensive. COST £ 150 – £ 1250 depending on the facilities used. (NOTE: By 2011, BP was not able to verify whether at home procedures still took place. Check The Stapleford Centre, London for more info.)

Some medical insurance companies may cover the cost of inpatient treatments and implants and local NHS health authorities are sometimes willing to pay for them.

Subutex and Suboxone

Many NHS GP’s also prescribe naltrexone tablets to aid abstinence (check out subutex – a partial agonist containing the drug buprenorphine,  which could be called a half way version – see Subutex on our  Substances webpage. Also, there is Suboxone – just like Subutex but with a tiny amount of Naloxone in the pill, which works only if injected; in other words, its aim is to discourage people from injecting their buprenorphine pills.) See our Substances page for BP’s take on Suboxone.

Naltrexone and it’s future

Naltrexone is used in many countries such as Britain, Australia, America and Israel and is currently to be seen making its way into other drugs – or rather, its close cousin Naloxone – which is now mixed with the drug buprenorphine – to become Suboxone. And Naloxone is also undergoing trials coupled with methadone, again, to deter people from injecting their methadone.In some countries such as the United States, an extended-release formulation is marketed under the trade name Vivitrol, which has been discussed more recently (2011). Also in the US, Methylnaltrexone Bromide, a closely related drug, is marketed as Relistor (US) for the treatment of opioid induced constipation (interesting use for Naltrexone but it makes sense as it excels in expelling opiates from the brain, and certainly does bring on the urge to go to the toilet!).

Depot injectable naltrexone (Vivitrol, formerly Vivitrex, but changed after a request by the FDA) was approved by the FDA on April 13, 2006 for the treatment of alcoholism. The medication is administered by intra-muscular injection and lasts for up to 30 days. Clinical trials for this medication were done with a focus on alcohol, presumably due to the larger number of alcoholics that it could be used to treat; however, however, a safety study for the off-label use of the injection for opiate addicts was also run. This was found to be a successful use of the medication in patients who were single drug users, as it seemed that multi-drug users would generally decrease their opiate use but increase their use of other drugs (i.e. cocaine) while on the injection (we know that story…). Other studies, however, provide preliminary evidence that naltrexone with the right protocol can be effective in treating cocaine addiction.(BP will look into this further).


While it may help those who are really determined to stop using, it is always important to realise that the battle is only half fought by naltrexone. It stops the effect of the opiate drugs which can of course be a huge help, however it does not stop the urges for them. And sometimes, those urges can be overwhelming and have lead to people taking out their implants themselves, taking extremely high doses of opiates in order to ‘ get over’ the naltrexone, or end up with habits on other drugs such as sleeping pills etc.

People have also talked about their experiences of depression when taking Naltrexone, and while we aren’t sure just what happens in terms of our delicate brain chemistry when taking this drug, it does perhaps make sense that this could be an issue however, it is often the issue when people stop using opiates and have to tackle living their lives without them.

As previously stated, if you’re on methadone it is better to transfer to another opiate before detoxing because methadone can make withdrawals more difficult, certainly they will take longer. Fears have also been raised about pain relief options while on naltrexone treatment. The bottom line is, that if you are in a serious car accident etc and need some immediate pain relief, you will have to wait approx 3 days to a week before you could feel any opiate based pain killer such as morphine. In the meantime you would have to make do with non opioid analgesics (ketamine, nitrous oxide etc) which are known to be weaker than opiate based drugs in terms of pain relieving capabilities. This can and has endangered lives.

Side Effects

Naltrexone’s side effects are said to be very mild. You don’t experience any withdrawal symptoms when you stop taking it. Adverse reactions such as; difficulty sleeping, anxiety, abdominal pain, nausea and headaches and some reports of severe depression – have been reported but might not necessarily be caused by the medication, they could be related to post detox blues…But depression has been cited a lot by our peers certainly – and from a medical point of view its quite likely that because of the way it affect endorphins, depression is very likely. Make sure you have loved ones around whenever possible.

More information available from Dr C Brewer of the Stapleford Centre 0171 823 6840. References ; NUAA NEWS Vol 25,27 (1998), Stapleford Centre, Brewer, C. (ed) (1993) ‘Treatment Options In Addiction; Medical Management of Alcohol and Opiate Abuse’ The Royal College of Psychiatrists, Gaskell, London SW1

Leave a comment


  1. Joshua

     /  February 28, 2018

    Been off heroin for 30 days. Been taking Naltrexone for the last 5 days and took a tablet this morning. I smoked 2 points of heroin a while after taking my tablet. Will I be sent into withdrawal tomorrow when i take the pill again?

    • no -which you probably know by now -just the heroin wont work….you need to have a habit on opiates -in order for the nalrexone to knock it out of your receptors and thus make you sick. No habit – no sickness from Naltrexone. Good luck with things -its a long road, just ride the cravings -like surfing -they do pass!

  2. Brad

     /  April 27, 2017

    I am on Suboxone (6 mg) and I’m going to a 3-4 day detox soon. When I get out of the detox I’m going to a vivitrol program. But before I get the shot, they want me to take naltrexone pills for 7 days before the shot. My fear is that the naltrexone is going to make me sicker than not taking it. I don’t want to throw myself into severe withdrawal. I Kno Suboxone can linger around a long time. So I’m affraid I’m going to make it harder on myself than just plain detox will be. How long do I have to be Suboxone free to begin naltrexone then to vivitrol?

  3. Chenoa Barnett

     /  March 16, 2017

    I just left a rehab and had seven days clean and called about a vivitrol assessment. They told me it would take a couple weeks to get in, so I went out and did a Roxy because I figured it would be out of my system by then. Well, today that called and said that they could get me in for land tomorrow. Is the oxycodone in my system automatically gonna kill my chances. All my withdrawal symptoms are gone… I don’t know how it works!

  4. LeAnn Jeanne

     /  November 26, 2016

    Im a single mother of twin toddlers and i REALLY need to stop drinking and taking rx pain medicine but I have no help or support. I can’t even entertain the thought of rehab or detox because i literally have no one that could help with my children while i was gone. Addiction runs like wild fire in my family and my brother was in the same boat as I am in now awhile back and he SWEARS by naltrexone as an aid to help him remain sober. I know it sounds like such a stupid question but how do i bring this up and suggest it to my dr?? He’s been my dr since I was a kid and almost like a friend of the family so that makes it even harder bc he knows all my family members very well.

  5. Loretta

     /  October 12, 2016

    if I have been clean for 7 days from heroin use, but still test positive for opiates how bad would the withdrawals be if I took a naltrexone pill

    • Ahmed

       /  May 18, 2017

      I waited 1and a had day and done it I went the the worst pain for 2 days no sleeep get clean first but ur saying 7 days u should be fine

  6. Paul Root

     /  August 4, 2016

    My wife was put on Naltrexone for sex addiction. She has been taking 50mg in the a.m. But that had been making her tied and nauseated during the day. She is switching to p.m. Dosing instead. That said, she took her last dose this morning at 0900, should she wait till tomorrow night to start p.m. Dosing or would it be ok to start tonight only 12 hours from her last 50 mg dose?

  7. Will98

     /  July 28, 2016

    URGENT, I just did a very small shot of heroin JUST enough to feel a little..I am gonna be forced to take a 50mg naltrexone tablet later this evening. Will I go into withdrawal? PLEASE HELP answer I am nervous

    • Shit sorry that this reply is too late for you! You will only be sick IF you have a heroin habit – then you will be pushed into withdrawals. If you have just used this once -and do so here and there -and so do not have a habit (eg you are NOT dependent on heroin and feel sick if you dont get your fix) then a naloxone tablet wont hurt you at all. You have to have your receptors full of opioids to start with, for them to be painfully and completely evacuated by naltrexone. Do let us know though if you were in pain from taking the naltrexone?

  8. URGENT – I MUST DO SOMETHING IMMEDIATELY – I was on Naltrexone for a wk or so, 50mg daily, started drinking again. Would it be harmful to take 2 daily, & if not 2 at a time or spread . Of course I mean a total of 100mg a day. Your rapid response would be most appreciated. Thank You

  9. evelyn

     /  May 5, 2016

    I have prescribed LDN for chronic pain, neuropothy and a couple of other chronic conditions. I understand from the posts that this can cause headaches and depression which I suffer from before I started taking this med. I have taken it for a week and the depression and migraines have worsened. This med has not done anything for the chronic pain. Should I keep on taking this and give it a chance? Or, is this something my doctor is getting a kick back from the drug company? He did say this is experimently for my conditions and is not FDA approved for chronic pain.

  10. I just had the naltrexone implant. I had to — my family forced me to because of my constant subutex injection habit. I’d been doing it for years but have functioned fine this way. The withdrawals have gone, but I’m so depressed and my cravings for injecting have not gone away. Obviously if I inject subutex I’m going to be very sick… What options do I have? I don’t feel I Have the strength to become a totally sober person. Will speed work while I have the naltrexone implant? Somebody out there who KNOWS, and won’t judge – tell me what will work while this thing is inside me. Without it making me go into withdrawals.

    • i just remove it yesterday the whole implant my self i made 9 stitches long because it was moving i removed it with my hands the pain was extreme but i was forced to put it so i dared them and i said even if i died i cut out to convince them that they cant force me to do shit its an orange pill tow and half Cm. long 7 Ml. width the problem is i cut out after its been in my body 5 days N.B its 6 month implant.
      the problem is that i don’t fell the effect of H since i cut it out the question is when the implant blocking effect will end i m going mad.
      please advise. Your fast reply would be highly appreciated.
      Karim Kassas
      Marketing Manager.

      • Hanna

         /  October 30, 2016

        Please would you tell me after how long did u feel heroin again? Cuzz i have the same problem, i cut it out three days ago and still cant feel shit please heeeelppp

      • Hanna

         /  November 4, 2016

        Heyy i have the same problem, i cut it out 10 days agoo, and still cant feel heroin, how long this shit takes to be out of my system

  11. Tracy

     /  April 10, 2016

    I took one naltrexone 50 mg yesterday by accident. I have never even heard of this med before I honestly thought I was taking Naproxen for my head ache. I feel so stupid about all this I seriously felt like I had been poised so I went directly to the ER. I told them what I had taken so they flushed 3 bags of fluids and nauseous meds through me for 3 hours to flush the med out of my system. I was just in the ER the day before for a infected ulcer in which I was given fluids, nausea meds and some pain meds….. I went home feeling ok.. Got up went to work and when I came home I went to grab naproxen for my head ache and grab something else instead. It looked like Naproxen so I didn’t question it at all well I took it and almost immedectly I had violently vomit and go to the bathroom…. Then I became cold with chills like I could t stop shaking….. The doctor said since I don’t normally take this kind of stuff that with all the fluids it should be flushed out of my system… What’s your take on this??

  12. Ann

     /  February 19, 2016

    Urgent, I just started taking naltrexone and all I can do is sleep. I feel sedated. I take it at night and then can’t stay awake all day. Should I stop taking it?

  13. Sherry

     /  February 4, 2016

    Does the online Naltrexone really work the same without a prescription?

    • should do if you trust the source. Be extremely careful though if you are going to start using it when you still are on a very small bit of an opiate. Do your research or you could end up with withdrawals times 100 happening with NOTHING in this world to help you! Do your research – we will write up more on Naltrexone over the coming week. be careful! Only use it when you are drug free ok? Otherwise you ought to be using a partial agonist like subutex -but again only after reducing down to about 20mls of methadone for a few weeks -then a 6 week reduction of subutex, then off, then the naltrexone to keep you off. Unless its for an alcohol issue?

  14. Claire

     /  January 6, 2016

    Urgent-I am not opiate dependent and got prescribed naltrexone to curve alcohol cravings, however I have sustained a back injury and was recently prescribed Vicodin. My question is, will the Vicodin still work on the pain, I’m not interested in the high just the pain relief, or will naltrexone block the painkiller all together. I cannot work with the pain I’m in, and will be starting PT for it next week, but until then I need pain relief and naproxen (aleve) ibuprofen and Tylenol don’t even touch the pain. Any answers? Thanks

  15. Terena

     /  December 30, 2015

    I took naltrexone pill and had a very bad experience for 3 days. Should I take it again or wait.? I had little suboxone in my system before taking the naltrexone pill by the way..

  16. stevie

     /  July 27, 2015

    Hey guys and gals need some advice please been on naltraxone for a few year’s now was going through a bad patch and decided to have a crack bender which I have never done before because cannot handle being wired stupidly I thought I would be fine if I took enough valium to knock a horse out 60 mg to be precise it’s not touched me so my only other option was to inject as much gear as I could to try and beat the blocker I don’t know if I managed it cause obviously cannot feel the gear my concern is took my last naltraxone 50mg 24 hours ago and my mum is about to force me to take my usual daily dose many years ago took a naltraxone an hour after a bag and 9 hours of fitting and shiting myself well all I can say is I would not wish that on my worst enemy so I am scared to death that will happen again but if the naltraxone is working and I have not managed to beat it I should have no adverse affects or will I any advice would be greatly appreciated

  17. Sylvia Garrett

     /  May 25, 2015

    Can naltrexone cause a drug test to be negative for opiates, if opiates have been ingested?

    • Caryn

       /  January 31, 2016

      You will still test positive for opiates if you have taken them within 72 hours of Naltrexine.
      You will not feel the euphoria from opiates as this new med is a blocker and binds to the opiate chemistry but the narcotic is still being digested just the same

    • Caryn Bradford

       /  January 31, 2016

      If you have ingested any drug within 72 hours they will show positive on a drug screen.
      Longer for Marijuana.
      It’s a blocker, that means you don’t feel the affects of your drugs, even when your system is flooded with them.
      My advice to you is if you want to pass a drug screen, lay off the drugs.

  18. Tray

     /  November 12, 2014

    Hello i have been taking half of a suboxone every morning for a few years. I have run out and i do have a few 50 mg. naltrexone pills. I didnt know if maybe i wait until tomorrow morning, i didnt take my suboxone today, so it will be 48 hrs if i do wait, to take a half of the naltrexone pill? Will i feel withdrawals if i do take it tomorrow? Or am i ok to take a half today? I dont care about any high at all, i just dont want to be sick. Thank youuuuuu

  19. Kelly Devaney

     /  May 25, 2014

    I take 100 daily dose of Naltraxone but have been off of them for 48 hrs am i safe to take an opiate, Thank you

  20. defeated

     /  May 20, 2014

    i’ve been through rapid opiate detox at the foremost clinic in beverly hills, california, not once but twice. each time (post op) they implored me to take my naltrexone, not as insurance from getting high should i use opiates, but–upon their insistence–the naltrexone would bind with the receptors that increased during my opiate (ab)use, the result being a reduction in cravings, since those receptors would then be at least occupied with naltrexone. the literature i read, however, says that naltrexone does noting to help cravings, that the only benefit it offers is a blocking of opiate high should opiates be used. can you speak to this? thank you.

    • Hi Defeated. As you say, naltrexone helps people overcome heroin/opioid habits by blocking the brain-cell receptors which allow these drugs to have pleasurable effects. There is evidence that it can directly reduce craving for alcohol, but there’s no evidence that it does the same for heroin/opioids. But the longer you abstain from heroin/opioids – with or without naltrexone – the lower your cravings should eventually become. However, even with a reduction in craving, it’s still possible for users to suddenly relapse due to stressful life events or for no obvious reason at all. Because of the high chance of relapse when you start abstaining from heroin/opioids, naltrexone can help you remain abstinent because you won’t get a buzz should you decide to use heroin again – making it easier to avoid falling back into a habit.
      Answered by: Dr Nuke

  21. michael napierala

     /  March 17, 2014

    hi my name is michael and ive been a IV heroin user for 2 years now and just today was told about naltrexone. my friend had told me that if im sick of going through the normal long withdrawal i could take naltrexone to shortin the withdrawal time. i understand it will be more intense but was just wondering what peoples thoughts were on this and if its even true that it makes it go by faster?

    • chris

       /  September 15, 2014

      Its quicker but my experience was horrific ended in hospital thought I was gonner die. Don’t advise anyone to use it to quicken detox . chris

      • Yes, you are pretty spot on to be fair. The fast detoxes using naltrexone and major indeed, and tho they usually drug you so you go through the concerntated withdrawals pretty tranquillized, you still go through a tough time. And yes, if you use naltrexone alone when you have no sedation and you also have an opiate habit, you are going to feel like you’ve been dragged through hell backwards!! It maybe quicker than usual cold turkeys but it will be rough as fuck! Naltrexone is best used when you are detoxed from heroin, THEN a patch is worn or tablets taken (or implant) with the idea that it is hopeless to use any opiates on top of it – they just won’t work. So….naltrexone is a useful addition in our arsenal of detox drugs, but for the right person at the right time, if that’s what/how they aim to detox. But your right, it is a baaaaad idea to use naltrexone when you are opiate dependent without any sedation or medication to support you thru the horrors!! Same with subutex – never take it when you are on any long acting opiate like methadone (over 25-30mls) coz you’ll have a very similar nightmare experience as naltrexone. Use subutex for detox or use, ONLY if you are under 20mls methadone (and you wait 24hours at least for it to leave your system) or your last heroin hit was at least 6-10hours ago, longer the better! Subbies are great for detoxing though -opiates – last injection at least 10-20 hours before, THEN take a subbie, wait, take another (2mg or 8mg a time) and level out when you feel OK, and decrease subbie dose over 6 weeks, til off. Its probably the best way to detox these days. Although it does seem after years of knowledge now that the longer you stay on subutex etc, the harder it is to detox, or rather, it is not as easy as it would be afterjust 6- 10 weeks of using it. Sorry you had such an awful time, but if it makes you feel any better, you weren’t alone!! Common mistake to make to be fair. Best wishes, BP.

    • Caryn Bradford

       /  January 31, 2016

      Under sedation in the care of a healthcare professional is the best way to detox with Naltrexine.
      You sleep through it all.

  22. Ray W.

     /  January 10, 2014

    very urgent question. please respond as soon as possible.

    hi, i currently have a naltrexone inmplant. i was fitted with one thats suppose to last 2-3 months. its been exactly 2 months yesterday and my implant is completly gone. i am unable to afford getting another one untill 1.5 months from now. my question is this. i need to know if my receptors are still blocked. if they are not then i can afford to go get the 30 dat vivitrol shot to hold me over untill i can get another long lasting implant. i am unable to get intouch with my doctor and i cant seem to get any concret answeres as to how long will i be blocked if the implant is physically gone from the internet for some reason. iv done alot of research and nothing so far. please help with any information possible. my name is ray. i really dont want to relapse. iv been doing really well for 2 months now and my life has imploved dramaticly. any information would be greatly appriciated.
    also i know this information may depend on my body chemistry.
    i am a man or 25 years of age. 5 foot 8 and 135 pounds. lean skinny athletic build. i am a smoker and i maintian my health and eating habbits.

    • Hi, Im so very sorry to have responded to you so late – I guess I also operate on Junkie time, so sometimes replying is hard -especially when BP is such a small voluntary operation. But enough of that -thank you so much for writing in to us. Would you like to ring me? Ill email you directly now with a phone number and Ill see if there is any information I can help you and your brother with. I have a couple of ideas….Ill email you my number now Ex

    • Hi Ray,
      (I think i mistakenly sent you an email to ring me – just ignore it, it was for another writer who is having some problems, sorry about that!!) RE our question – ill do some research but almost sure that your receptors would become unblocked once the implant was fully gone. You will of course have NO tolerance and overdoses are very common at this stage as people begin to ‘reward themselves’ with just a little hit, just to see, just this once….Bad idea. There is nothing to say that we cant moderate and control our drug use, millions do, but millions struggle as well. You have to know yourself veery well from here on in, trust yourself, listen to your instincts. If you feel that little naughty kid sitting on your shoulder when you are wanting to just hav a dabble, search yourself long and hard annd ask ‘am i going to be able to stop with this one? Drug use is fab, but habits arent. Sometime the two are impossible to unleash. You seem to know your own mind, and are very keen to keep going. It shouldntt then matter whether the naltrexone is still there or not then. It is up to you now. Be strong. We wish you peace and good luck my friend. BP x

  23. My doctor has rx’d naltrexone for me for drinking , but she doesnt want me to stay on it for too long because she thinks it might have some effect on my liver, but I think the drinking on my liver coukd be worse! Ive had an ultrasound , everything was fine , all my labs are perfect, I can see slowly lowering the dose as time goes by , but alcholism is a disease and shoukd be treated as one just like a diabetic, I guess we should taper them off of insulin! I am a registered nurse and do know somethings, I really want to quit drinking but I want to know if there are people who have taken naltrexone for years.

  24. Can a person stay on naltrexone for ever ?

  25. Jon

     /  November 10, 2013

    Thanks for this article. I have found naltrexone invaluable in staying off opiates over the last couple of years. I have had slips, but it would have been so much worse without.

    However, getting it prescribed can be difficult. I have had GP’s refuse to do so without a referral from a tier 3 service. They will then refuse to continue scripting unless the service recommends it. It can be difficult to engage with these services, if you work 9-5, and I found them trying to push me off of the drug after 9 months – I believe they have targets concerning discharging of clients and stuff, these days (possibly something to do with “payment by results”? I’m not really up to date on current policy, but I hear bits and bobs…)

    I can understand the need for only tier 3 referrals for opiates, as GPs are usually not addiction specialists and there are inherent dangers in prescribing these drugs without proper assessment, dose titration, etc. However, I’m not sure the same applies to naltrexone.

  26. Moonwatcher

     /  July 19, 2013

    To my knowledge, Naltrexone experiments have been published not only in the treatment of alcohol and heroine addiction, but also for treating eating disorders, gaming and gambling, shoplifting and sex addiction. Low Dose Naltrexone is being promoted on the website of LDN for treating patients with MS, ALS, HIV-AIDS, Crohn’s Disease, Cancer of the Pancreas, and a list of other auto-immune diseases. Unfortunately, the conservative medical world is not at all happy with this miracle drug, and rather stays behind the big pharmaceutical industry ! Knowledge of the treatment is being withheld from the great majority of addicted prostitutes and inmates in most countries.

  27. Nick WIlliams

     /  March 5, 2013

    Hi Rebecca,

    I’ve been researching Naltrexone for a friend of mine. is your treatment an implant or injections? What treatment center are you using?

  28. Rebecca Ryan

     /  February 4, 2013

    I am taking Naltrexone to stop drinking. I am impressed so far as I am only four months into my treatment. The depression is real. At least is was for me. I thought it was logical considering the Nal was blocking all endorphins so that would make it hard to find joy in just about anything right? Anyway I added Lexapro and all is great now. I am so glad I stumbled across this cure before I became a full blown alcoholic.

    • Thanks so much for this insight Rebecca! A friend is about to start taking subutex (a partial agonist – as opposed to a full antagonist like naltrexone) after many years on opiates. He was worried about potential depression (the last thing you need when getting off drugs!) for the very reason you have mentioned -figuring that the subutex would be emptying out endorphins and blocking off any new ones entering….Its not rocket science for one to assume depression lurks close by! However, from our experience and research, subutex doesnt seem to depress mood, in fact many have said the opposite (in particular those who have transferred from years on methadone, which really can be depressing!). Naltrexone however, is a different story – people do report depression -and thats tough when you so desperately need to keep the ‘black dog’ at bay while one makes that huge adjustment to the straight world. So, you found adding an antidepressant (SSRI isnt it?) really helped redress the imbalance? Makes sense. Just a word however, SSRIs should be used as a tool, giving your nervous system a break as you pull your life back together. Use them combined with either practical steps forward (using useful tools such as CBT or Cognative Behavioural Therapy) or psychological counselling/therapy and work towards coming off them after 6months-ish (ideally) -to a year, and you keep control and on top of the drug. It is very, very easy to let the days and months slide and before you know it 18months have gone by, they dont seem to work anymore, and you become fearful to come off them as withdrawals work to increase your anxiety making the whole experience of getting off them quite intense. Thanks so much for the tip, wishing you the best with everything, and, with SSRI’s keep it brief, keep in charge, and use them as a tool to get back on your feet (and not as an unwanted interloper who has outstayed its welcome! Thanks again! if you like to write a few words on how your detox went, we’d ;love to hear about it. In solidarity, BP

  1. Naltrexone | Black Poppy's Junk Mail

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