Ketamine

 

Ketamine dried and scraped

Ketamine dried and scraped (Photo credit: Wikipedia)

There are clearly 2 parts to this article; 1st section is about how to use it to best effect without freaking yourself and others out or getting robbed or groped etc that BP has carefully put together.

The 2nd Part is also very necessary as it is definitely one of the best low down on the pharmacology of ketamine I’ve seen – and there is a link to their site as well. Brilliant stuff from them.

NOTE: Here is a link to an updated piece on Ketamine use by one of the UKs leading drug user activist’s Mat Southwell. A presentation made at the Advisory Council for the Misuse of Drugs, in May 2013. Slides and text show the latest information on Ket and bladder problems amongst other things. Well worth a visit, click here.

 

PART 1

CONTENTS: Dose…If you are out & about… Prepare your journey well… Environs…Questions, questions, questions…What to take with you?.. Where to go?… Who’s first?…K and sex?…KETAMINE CHAOS!…WARNINGS!… Other Ketamine Links

Ketamine is an unusual drug and people have found themselves freaked out, hurt, robbed or groped – all because they weren’t aware of Ketamines ‘disassociative’ aspects. Although K only lasts between 15-40 mins, it disassociates the mind from the body, so you won’t be able to feel or control your body with any certainty. It may be impossible to walk, run, or even move at all – all of which can be dangerous if you suddenly find yourself in a dodgy situation. There’s some particular info it’s good to know about with K, even if you think you know it all anyway coz you take K all the time – here are some trips to stay safe and get the best out of your K experience. Read these tips for safer K trips. (Another article on how K works as a drug, its history, its drug culture etc, is following shortly, stay tuned to our site).

Dose:

The strength can vary with K, depending on how it was cooked up but it is safe to say that small amounts are best for a couple of reasons: Firstly, You may not like it. K doesn’t last long, so if you find it doesn’t suit your taste or you don’t like the mood then it will be much easier to manage a smaller dose than if you end up shot through a K-Hole and are totally freaked out for 30 mins. Using smaller amounts will also help work out your tolerance level and will give the option of deciding just how far you want to go – and enable you to get there and back safely and smoothly. Small incidentally, being about 20mg for the inexperienced K user (say the size of half a line of coke)

If you are out & about:

If you are out and about take K in ‘bumps’ or very small lines, you WON’T need as much as you would use with other powders. While it is highly unadvisable to take K anywhere that’s not safe and cosy, by taking K in small bumps instead of lines, you MAY still be able to maintain some control over your muscles/body movement – or you may find yourself suddenly careering into a pole or falling over, losing coordination very suddenly – and possibly dangerously. Never try to run on K, you’ve been warned! Your movements will be impaired on Ketamine, in fact you may not be able to move at all, so protect yourself from unwanted sexual attention or robbery by surrounding yourself with good friends and don’t take K with strangers. Moving or dancing could lead to problems – and as you may not feel any injuries till later, it’s better to stay put..Ketamine and alcohol combined sometimes leads to aggressive behaviour, so pace yourself.

Prepare your journey well.

To get the most out of your K experience, A&E suggest choosing close friends or lovers to share the experience with. Moving around is not recommended so make sure everything you need is within arm’s reach: the remote control for the stereo or TV (see below), a glass of water, pillows for extra comfort if required, your K if you find you need to top up, and just to be safe – a telephone so you can call someone if something goes wrong. Remember, your immediate sights and sounds will be with you for your entire journey, so make sure you’re comfortable, safe and you’ve got what you need because depending on how far you’ve gone – you may not be able to make any changes until it’s finished…

Environs:

A&E suggest getting comfortable. Lying down with your pal is good, lying back in a deckchair (one of A’s favourites) or reclining chair are all good ways to enjoy K. We suggest, especially for first timers, you take your K indoors (see K Chaos overleaf for reasons why).

Carefully pick the music as this will be with you throughout you K experience. Some people have their favourites (A has a preference for Kylie in a K-hole, E likes something ethereal). Noisy banging, thumping tunes aren’t really what you want. Make sure however, it’s on continuous play, so you won’t have to get up to change the CD. TV & cool videos can be an interesting experience, as is staring at the stars ( E prefers completely closed eyes for that inside out feel!)

Questions, questions, questions…

Questions, questions, questions: you may get a few big ones thrown at you whilst on K – but you don’t have to find the answers right away. The more you relax, the more pleasurable the ride.

What to take with you?

What to take with you? An open mind. If you enter the experience feeling and thinking the worst, the more chance you will have of going somewhere you may not want to be. So take a good vibe with you – and enjoy. Animals can be a bit of a barometer of where you are. You may find if they are beside you, purring or breathing, they may act as a beacon to help anchor you with some sort of reality. (They can be very intuitive too). It must be stated here though NEVER EVER give any animal ketamine (or ANY drug), despite its associations as a vetinary anesthetic, it has been known to have very serious consequences if given without other specialist vetinary medications. Never do it.

Where to go?

Where to go? Dilemmas, dilemmas! Some people go astral travelling, guiding their K experience. Others talk of regressing into past lives and others still, visit planets and far off lands. You can actually go somewhere together or even as a group, holding hands and communicating telepathically. Don’t rush, don’t push, just gently guide..

Who’s first?

Because K is so short acting, one person could go first while the other watches over them to make sure they’re ok. This is a good idea either for beginners, or for those wanting to experiment and go further out (or in!). The amazing thing about K is that even if one goes first, your pal can always catch up to your level later.

K and Sex?

Sex is possible if you haven’t taken too much (now we are talking about a tiny bit here, a ‘bump’ or about a 6th of a usual line) and can be a wonderful experience – but remember – it’s all about who you are with – you might not be able to negotiate safer sex (using condoms could seem very complicated, erections mightn’t sustain a condom either so it could easily come off inside a woman mid way through sex) so don’t go there if you can’t be safe! There is a lot of nice touching you can do without having to actually have sex and touching with K can be a very spiritual experience (although only when you’ve had a little, having too much means you won’t even know you’ve got any legs let alone feel someone touching them!). Don’t take it with people you aren’t completely sure of or make sure you have a friend present who hasn’t taken Ketamine to keep an eye on you. This goes for being careful about accepting drugs off people you don’t know – imagine being in a place you don’t know, with people you just met, and have just snorted a big line of K and can’t move or defend yourself. Nightmare stuff.

KETAMINE CHAOS! WARNINGS!

Don’t operate machinery or electrical equipment – it will be as confusing as fuck and could be dangerous! Who wants to strip down a car when your on K anyway! Keep away from swimming pools, cars and dangerous dogs for the same reasons. You wan’t to be able to appreciate K’s effects if you are stumbling around, trying not to fall over, worrying about people knocking on your door etc. Lie down, chill out, and stay safer.

Time: You will have NO CONCEPT of it. Time moves very slowly with K so looking at your watch will just confuse you. Don’t try and work it out, a digital clock nearby will be better and it may also provide amusement!

Headfuck: If you are someone who is very emotionally vulnerable, or has a mental illness, you probably ought avoid K as it is proven to be quite a headfuck and it can be psychologically addictive. It can also be emotionally draining as well so its very important to give yourself a decent break between K Trips.

Don’t Panic!: K generally only lasts for 20/40mins, so if you get scared about where you are, try not to worry, YOU WILL come through the other side. Just relax.

Girls and Guys: It is common sense really but on K, your movements will be impaired – you may not be able to move at all – so protect yourself from unwanted sexual attention and do your K with best buddies, not strangers. Read the sex bit above for extra info

Mixing it up: K really is best on it’s own. People have encountered problems when they’ve taken it with alcohol (it has caused people to lose consciousness and choke on their vomit or to get violent or aggressive). It is no where near as nice when you mix it with alcohol anyway and the above are extremely good reasons why not too do it. The other drug people sometimes mix it with is cocaine. This can cause it’s own sort of problems as you might get coke’s energy to be able to walk around, but then BAM! All of a sudden your legs will go from under you and you could end up falling down stairs, in a pool, etc, breaking a limb or worse… We can’t emphasise enough the idea of STAYING PUT when you take K.

Walk, Don’t Run: Try not to get up and move around – the disassociative aspect to K will make movement difficult and you could fall and hurt yourself. Its anesthetic properties could make you unaware how seriousness an injury may be. So stay put, you’ll be back in 30 mins!

NEVER: Use Ketamine when you’re pregnant. And ever mix it with Absinthe, alcohol, MAOI’s (which are some kinds of antidepressants) GHB, Yohimbe, major tranquillizers (anti psychotics) OR if you have kidney impairment or liver disease, high / very low blood pressure, or are epileptic.

Compiled by A & E Lifestyles: A BP partnership in drug taking and investigating. Taken from a BP leaflet, which was based on an article from issue 8.

Dr Andy Tomlinson: A good medical article on Ketamines effects on the body.

Ketamine Bladder Syndrome: Good info on KBS

John.Lilly

A ‘Face’ on the Kay scene; John Lilly -Ketamine researcher & user

(Ketalar, Vetalar, Ketacet, Ketajet)

Ketamine [2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone] is used as a general anaesthetic; in pain management to reduce opioid tolerance and withdrawal; in controversial drug-assisted psychotherapy; recreationally, as an ill-named “club drug”; and as an experimental tool to investigate the properties of mind. Sub-anaesthetic doses of ketamine may induce feelings of euphoria, dreamy detachment, deep mystical insights, loss of normal time sense, “floating” weightlessly away from one’s body-image, and an altered phenomenology of thought. Some users report merging with inanimate objects, vivid “near-death” experiences, extraterrestrial beings and meeting God – or Satan. By common consent, experience of the “K-hole” cannot adequately be captured in words. Ketamine-inspired insights are also hard to integrate into the rest of one’s life – not least because the drug induces significant amnesia. When ketamine is administered at higher, anaesthetic doses of 1 mg/kg intravenously, the subject may stare blankly into space with his or her eyes open for 10 or 12 minutes, still retaining significant muscle tone but unresponsive to environmental stimuli. This state of detachment was christened “dissociative anaesthesia” by University of Michigan researcher Edward Domino, who credits the term to his wife. The two classic dissociative anaesthetics are ketamine and phencyclidine. * * * Compound CI-581, soon renamed “ketamine” (Ketalar, Vetalar, Ketanest, Ketaset, etc) was first synthesized in 1961 by Calvin Stevens at Wayne University. Stevens conducted further research at the laboratory of Parke, Davis and Company from 1962. Researchers at the pharmaceutical firm were looking for an agent with less severe behavioural side-effects than the structurally related phencyclidine (PCP, Sernyl). Ketamine was first tested on humans in 1964. The subjects were volunteers from a state prison in Michigan. Ketamine was widely employed as a field anaesthetic by the U.S. army during the Vietnam War. Ketamine is a shorter-acting and less potent compound than PCP. It is a valuable anaesthetic for certain medical procedures, especially involving children; for use in asthmatics (ketamine is a bronchodilator); or where the patient’s medical history is unknown e.g. after a traffic accident. Ketamine does not induce the respiratory depression associated with barbiturate anaesthesia, so its therapeutic index is higher. The drug is also a potent analgesic. Ketamine is still widely used as a sedative and immobilising agent in veterinary medicine. So-called “emergence reactions” limit its use in human patients. Non-human animals probably undergo emergence reactions too; but they are unable to articulate them. Ketamine and its active metabolite norketamine are non-competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor. NMDA receptor channels open in response to binding of the excitatory neurotransmitter glutamate. These ligand-gated cation channels are implicated in synaptic plasticity and long-term potentiation – the neural bases of learning and memory. Use of NMDA antagonists can cause amnesia. NMDA receptor antagonists can also mimic various aspects of the “negative” symptoms of schizophrenia. Ketamine is available in tablet, powder, and liquid form. Psychoactive effects come on about 30 seconds after an intravenous injection; 2-4 minutes after an intramuscular injection; after 5-10 minutes via the intranasal route; and some 10-30 minutes after an oral dose on an empty stomach. The trip typically lasts 45 minutes to one hour. In three hours, the average user will have reverted to “normal” consensus reality of early 21st Century human primates. NMDA antagonists can suppress the symptoms of opioid withdrawal in chronic opioid users who decide to quit. Ketamine also plays an “anti-hyperalgesic”, “anti-allodynic” and “tolerance-protective” role, enabling regular opioid users to minimise their effective opioid dose. In 2006, Dr Carlos Zarate of the National Institute of Mental Health (NIMH) reported that a single dose of ketamine could dramatically relieve treatment-resistant major depression within hours of injection. Most remarkably, the sense of well-being induced in otherwise refractory depressives can last for up to a week. Zarate’s work successfully replicated and confirmed the pioneering research of Yale professor John Krystal in the 1990s; ketamine is off-patent, so research proceeds slowly. The mechanism behind ketamine’s antidepressant action is unclear; but activation of the AMPA subtype of glutamate receptors plays a role. Unpublished research from NIHM suggests that preventing AMPA activation inhibits ketamine’s mood-brightening effect. Unfortunately, the potential of NMDA antagonists as clinical antidepressants is limited by their psychoactive side-effects. Some subjects also find ketamine highly enjoyable – a shortfall rarely encountered with currently licensed pharmacotherapies for depression. Such subjects use the drug compulsively: ketamine increases extracellular dopamine levels in the reward centres of the nucleus accumbens. So the possibility of psychological dependence is high. Ketamine researcher Dr John Lilly used to take ketamine almost hourly for weeks on end in the Esalen flotation tank.

 

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2 Comments

  1. Paul

     /  October 22, 2015

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    Reply
  2. Inell Curts

     /  October 9, 2012

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