Drug Induced Seizures

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know your seizure 'triggers'

Many drug users may have experienced a seizure at one time or another –and you don’t have to be an epileptic to have a seizure.

[Epileptic] seizures can be very frightening to experience and to witness and although many ‘committed’ drug users/drinkers will have experienced a seizure at some point in our lives, there are still many myths that concern how to deal with a person who is fitting and a general lack of understanding as to what triggers ones seizure, or how to deal with it when it occurs. (look at OD Myths’ in Black Poppy 2).

There are two main types of epileptic seizures; petit mal (minor epilepsy where a person may momentarily lapse into inattention/ daydreaming without losing consciousness) and Grand Mal ( Major epilepsy) which is more serious with muscular spasms and convulsions and a short loss of consciousness. People who are epileptic may often carry an orange ID card or wear a warning bracelet. With drug use, it is the major type of seizure that occurs most often. This is usually from long term (or heavy bingeing) benzo or barbiturate use; A person may miss taking their pills for a day and find themselves fitting. However, seizures can occur alongside an overdose on most drugs, indeed they occur from too much alcohol, heroin, cocaine, ecstasy, antidepressants and many others.  Interestingly, everyone has what is known as a ‘seizure threshold’ meaning that anyone can experience one given the right conditions. (BP has an indepth article on seizures, see Issue 11 for our drug induced seizure update.)

It is certain that stress increases the possibility of seizures, as does menstrual changes, vitamin or mineral deficiencies, metabolic changes (including blood pressure that is too low or drug/alcohol use), virus activity and other things, such as trauma to the head area, with seizures more likely to  re-occur if someone has had them in the past.

It is important to get to know what ‘trigger’ your seizures as it appears that the more you get them, the more susceptible you become to getting them. Thus if you can find ways to reduce the likelihood of getting a seizure, either through using certain neuroleptic drugs and improving your lifestyle, you have more chance of getting rid of them. Most people do stop or ‘grow out’ of seizures, but they can come back when your body is struggling from one thing or another.

Many of us have experienced seizures starting through too much benzodiazepines use (or from stopping them too quickly). Seizures can still happen up to a few years after benzo/barbiturate use has stopped. (see warning signs).

For the rest of the article, click here.

Osteomyelitis

Big Name, Big Infection

After noticing an increase in the numbers of IV drug users who have been diagnosed with osteomyelitis, BP thought some investigation was needed as it appears to be an infection most of us know very little about, but which can have some extremely serious consequences if left untreated. Osteomyelitis is a serious bone infection which can occur in virtually any bone in the body although it usually crops up in the spine, foot or in long tubular bones such as those in the arm or leg, even fingers.

osteomyelitis - an extremely painful infection inside the bone, and one that can affect injectors.

While quite rare in many countries, there has recently been a rise in the numbers of intravenous drug users (IVDUs) becoming infected and this is particularly disturbing considering its often vague initial signs and symptoms which can mean diagnosis is often delayed. This, coupled with the problems IVDUs often encounter when accessing health care can mean that many users are suffering unnecessarily through late diagnosis.

This is a particular concern as some forms of the disease, such as vertebral (spinal) osteomyelitis can, if left untreated, lead to permanent paralysis, significant spinal deformity or even death. It can be an extremely painful infection of the bone and can take some time to heal so it is important for all of us to be aware of osteomyelitis and its symptoms so we know what to look out for. People with compromised immune systems such as cancer or HIV/AIDS, need also be very aware of this debilitating condition as it is often more likely to appear in people whose immune systems are not functioning well.

What is it?

Osteomyelitis is usually a secondary infection that follows an infection borne elsewhere in the body – perhaps caused by a wound, (such as an infected abscess), surgery, bone fracture, or a foreign body such as a surgical plate. IV line, urinary catheter or bullet. Once started, the infection can then spread to the bone via the blood and when the bone is infected, pus is produced within the bone. This can result in an abscess, depriving the bone of its blood supply. Early treatment can save the bone from destruction but as bone is hard tissue it is often resistant to antibodies and this can be difficult to treat.

Similar to infective endocarditis (BP issue 7 and BP’s A-Z of Health), osteomyelitis is usually caused by the same bacteria: Staphylococcus aureus (Staph. a). This bacterium can be introduced into the body in a variety of ways. Staph a. live intermittently on the skin in more than 70% of the population at any one time and the other 14 are colonized persistently. Those who use injecting equipment on a regular basis and inject in sites that are potentially Staph A colonized such as the feet, hands, groin etc can be at greater risk of attracting infection (see prevention). Again, this is why a hygienic injecting regime is essential for all IV users to help reduce as many factors as possible that could encourage an infection, (see overleaf & BP no. 7).

To read the rest of this important article on osteomyelitis and catch up on the symptoms, treatment, its relation to intravenous drug use and more, click here (from BP issue 8)

Hepatitis C

A simplified diagram of the Hepatitis C virus ...

Replication cycle of the Hepatitis C virus

Once known as Hepatitis Non A Non B, Hepatitis C is being discussed a lot in the using community. Here, BP goes behind the ‘Hep C test’ where many of us stop, discovering why further tests are so important in getting to the bottom of your own Hep C diagnosis.

In the last issue, BP ‘introduced’ the liver, briefly discussing what it does and how it does it. This issue, we want to look more closely at a virus that has affected the livers of an estimated 250,000 – 600,000 people in the UK alone, 170 million people worldwide with some 3 million more joining the global ranks each year. BP wanted to find some straightforward answers to some essential questions on Hepatitis C and what you may want to consider if you have been diagnosed Hep C (HCV) positive. (BP will look into treatments for HCV next issue).

Hepatitis C is?…

The actual word “hepatitis’ means inflammation or swelling of the liver. This can be caused by chemicals, drugs, drinking too much alcohol or by different kinds of viruses. Hepatitis C is just one of a number of hepatitis viruses (including A, B,D, E, G) and they are all completely different from one another. It can be hard to get your bead around just how small viruses really are. HCV is estimated to be 80 nanometers in diameter (around 30 billion would fit on this dot {,} – another reason why handwashing before and after injecting is so important; be especially vigilant if someone injects you after they’ve just had a hit – they could have microscopic particles of blood on their fingers and then may place them on your injection site. HCV is known to be remain active outside the body for some time so wash your hands and tell others to wash theirs! The hepatitis C virus is in fact a group of viruses, similar enough to be called HCV virus, yet different enough to be classified into subgroups.

Genotypes

Several families of hepatitis C have been observed around The world and these are known as genotypes, because they differ in their genetic make up. They arc usually classified as HCV genotype 1 ,or 2, or 3, etc. Some genotypes respond better to treatment than others so it is important to identify your genotype when considering treatment for Hep C..

Subtypes

Within each genotype, there are subtypes. These are classified as HCV subtype la, or Ib, Ic, etc and within a subtype, incredibly minute differences will exist among individual viruses, called quasispecies – several million quasispecies would exist within a subtype.

To read the rest of this BP article, and find out how Hep C can affect you, click here.

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